The PlA1/PlA2 polymorphism lies within the gene for your ?three (GPIIIa) subunit of ?IIb?three (GPIIb-IIIa). This integrin serves like a receptor for adhesive proteins fibrinogen and von Willebrand variable which is vital for the cohesive Qualities of platelets. Recognition of those proteins as soluble ligands necessitates ?IIb?3 to generally be ac